Viewing 1 - 7 of 7 results
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- Chapter 2: The Nature of Cancer
- Description:
- Normal human mammary epithelial cells can be grown in cell culture. They form structures that resemble the little sacs of cells called alveoli in which milk is made. Cells assemble into a well organized, polarized epithelium that ...
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- Chapter 3: Tumor Viruses
- Description:
- When normal cells are introduced into a Petri dish at low numbers, they begin to divide and proliferate. As the cells begin to touch one another, they stop dividing. This process is called contact inhibition. Once the cells fill ...
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- Chapter 5: Growth Factors and Their Receptors
- Description:
- The Ras protein is a representative example of the large family of GTPases that functions as molecular switches. The nucleotide-binding site of Ras is formed by several conserved protein loops that cluster at one end of the ...
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- Chapter 6: Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
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- The Src protein kinase acts as a molecular signal integration device. Src consists of three clearly demarcated domains: an N-terminal SH3 domain, an SH2 domain, and a tyrosine kinase domain. In addition, a linker and the short ...
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- Chapter 8: pRb and Control of the Cell Cycle Clock
- Description:
- Like other kinases, Cyclin-dependent kinases, or Cdks for short, are crucial regulatory proteins in the cell cycle. When activated, Cdks transfer phosphate groups from ATP to serine and threonine side chains on targeted substrate ...
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- Chapter 9: p53 and Apoptosis: Master Guardian and Executioner
- Description:
- p53 is a tumor suppressor protein that prevents cells from dividing inappropriately. Loss of p53 function is associated with many forms of cancer. In this image, p53 polypeptide is shown binding to DNA, reflecting p53’s ability to ...
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- Chapter Name:
- Chapter 9: p53 and Apoptosis: Master Guardian and Executioner
- Description:
- Programmed cell death or apoptosis has been induced in these cultured cells. Cell death is characterized by blebbing of the plasma membrane, which gives the surface the appearance of boiling water, and fragmentation of the nuclei. ...
Viewing 1 - 7 of 7 results
