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Molecular Biology of Assemblies and Machines

Alasdair Steven, Wolfgang Baumeister, Louise N. Johnson, Richard N. Perham
Publication Date:
February 18, 2016
Content Details:
852 pages

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List Price:   $165.00

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  • About the Book

    Book Summary

    Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine.

    Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.


      • Uses vivid illustrations to convey the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell.
      • Written as the go-to reference for advanced students and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.
      • Features a searchable glossary online, as well as flashcards, for testing student vocabulary.
      • Chapters contain boxes exploring difficult concepts in more depth and end with a curated list of references for further reading.
      • Two appendices provide a “Field Guide” to commonly encountered protein folds and descriptions of the main methods currently used in the practice of structural biology.
  • Contents

    1. The Machines and Assemblies of Life
    2. Chromatin
    3. DNA Replication
    4. DNA Repair and Recombination
    5. Transcription
    6. Protein Synthesis and Folding
    7. Intracellular Proteolysis: Protein Quality Control and Regulatory Turnover
    8. Assembly of Viruses
    9. Multienzyme Complexes: Catalytic Nanomachines
    10. Transport
    11. Connectivity and Communication
    12. Signaling
    13. The cell cycle and cell death
    14. Motility
    15. Bioenergetics
    16. Membrane Channels and Transporters
    17. Complexes of the Immune System
  • Instructor Resources

    Instructor Resources

    Art of Molecular Biology of Assemblies and Machines
    The images from the book are available in two convenient formats: PowerPoint® and JPEG.

    Animations and Videos
    There are 8 movies, pertaining to virus assembly, the cell cycle, cell motility, and bioenergetics.

  • Student Resources

    Student Resources

    Each chapter contains flashcards, built into the student website, that allow students to review key terms from the text.

    The comprehensive glossary of key terms from the book is online and can be searched or browsed.

    Two online appendices are referenced throughout the book where relevant.
    Appendix I: A Field Guide to Protein Folds illustrates the structure and topology of commonly encountered protein folds.
    Appendix II: Methods of Structure Determination describes the main methods currently used in the practice of structural biology organized by computational approaches, electron microscopy, nuclear magnetic resonance, and x-ray crystallography.

    Each entry lists key references for further study.

    Animations and Videos
    There are 8 movies, pertaining to virus assembly, the cell cycle, cell motility, and bioenergetics.

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