The Molecules of Life
Physical and Chemical Principles
- John Kuriyan, Boyana Konforti, David Wemmer
- Publication Date:
- July 25, 2012
- Content Details:
- 1,032 pages | 900 illustrations
Also of Interest
The field of biochemistry is entering an exciting era in which genomic information is being integrated into molecular-level descriptions of the physical processes that make life possible.
The Molecules of Life is a new textbook that provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
The book integrates fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure. The central theme is that the ways in which proteins, DNA, and RNA work together in a cell are connected intimately to the structures of these biological macromolecules. The structures, in turn, depend on interactions between the atoms in these molecules, and on the interplay between energy and entropy, which results in the remarkable ability of biological systems to self-assemble and control their own replication.
The Molecules of Life deepens our understanding of how life functions by illuminating the physical principles underpinning many complex biological phenomena, including how nerves transmit signals, the actions of chaperones in protein folding, and how polymerases and ribosomes achieve high fidelity.
- Noteworthy biological examples, many building from seminal discoveries, with key terms highlighted throughout the text.
- Important calculations and derivations explained in boxes.
- Qualitative and quantitative end-of-chapter problems, with selected solutions available online to students.
- Chapter summaries, with key concepts delineated by chapter section.
- Further reading and references at the end of each chapter.
"This is an excellent book that does exactly what it says on the front cover. The book is indeed written in what is now the standard format of a student textbook: very clear presentation with good graphics; special points highlighted in shaded boxes; with problems and suggestions for further reading at the end of each chapter."
- British Society for Cell Biology Newsletter, January 2013
Part I. Biological Molecules
1. From Genes to RNA to Proteins
2. Nucleic Acid Structure
3. Glycans and Lipids
4. Protein Structure
5. Evolutionary Variation in Proteins
Part II. Energy and Entropy
6. Energy and Intermolecular Forces
8. Linking Energy and Entropy
Part III. Free Energy
9. Free Energy
10. Chemical Potential and the Drive to Equilibrium
11. Voltages and Free Energy
Part IV. Molecular Interactions
12. Molecular Recognition
13. Specificity of Macromolecular Recognition
Part V. Kinetics and Catalysis
15. Rates of Molecular Processes
16. Principles of Enzyme Catalysis
17. Diffusion and Transport
Part VI. Assembly and Activity
19. Fidelity in DNA and Protein Synthesis
Images from the book available in JPEG and PowerPoint formats.
A solutions manual will be available for chapter problems.
Movies and animations will be available.
Answers to selected problems will be provided.
E-book and Custom Publishing
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