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Cellular Signal Processing

An Introduction to the Molecular Mechanisms of Signal Transduction

Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker
Publication Date:
November 14, 2008
Content Details:
656 pages

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  • About the Book

    Book Summary

    Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease.


      • Chapter 3 discusses the evolution of cellular signal processing by focusing on prokaryotic signal transduction, which links the major switching reactions of mammalian signaling to prokaryotic predecessors. This chapter is unique among the currently available cell signaling textbooks.
      • Chapter 17 places signal transduction in context with systems biology and describes the formation and function of networks.
      • Highly visual illustration program that features over 400 illustrations.
      • Sidebars are included throughout the book to highlight complementary perspectives to the main discussion and strengthen the student’s understanding of essential concepts.
      • Section summaries clarify the important points with each chapter.


      "This book would be highly useful to undergraduate students in medical, bioinformatics or biological science that are studying or pursuing research into signal transduction, network or systems biology.  This book would also appeal to graduate students or professionals moving into this field of research, without prior knowledge or experience....each chapter engages the reader and conveys the importance of biological systems and networks adequately, thus challenging the reader to continue viewing their specific focus or field of research in complete isolation." - Immunology News, November 2010

  • Contents

    1. The "Brain of the Cell": Data Processing by Protein Networks
    2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
    3. Evolution of Cellular Data Processing
    4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
    5. Signal Transduction by Receptors with Seven Transmembrane Domains
    6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
    7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
    8. Gene Transcription: The Ultimate Target of Signal Transduction
    9. Signals Controlling mRNA Translation
    10. Signal Transduction by Small G-proteins: The Art of Molecular Targeting
    11. Mitogen-activated Protein Kinase and Nuclear Factor ĸß Modules
    12. Cancer and Regulation of Cell Division
    13. Signal Transduction by Proteolysis and Programmed Cell Death
    14. Signal Transduction by Ions
    15. Sensory Signal Processing
    16. Signaling at Synapses: Neurotransmitters and Their Receptors
    17. Putting Together the Pieces: The Approach of Systems Biology


  • Instructor Resources

    Instructor Resources

    For the following resources verified instructors can visit the resource page for Cellular Signal Processing.

    The Art of Cellular Signal Processing
    Artwork available in PowerPoint and JPEG format.

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  • Downloads

    Samples & Downloads

    Download the Detailed Table of Contents from the book.

    Click on any of the links below to download a printable PDF of a sample chapter.

    Chapter 3: Evolution of Cellular Data Processing