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Genetic Association Studies

Background, Conduct, Analysis, Interpretation

Mehmet Tevfik Dorak
Publication Date:
September 26, 2016
Content Details:
230 pages

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List Price:   $93.95

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  • About the Book

    Book Summary

    Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.


      • Focuses on two types of genetic association studies: candidate gene studies and genomewide association studies
        1. A non-mathematical approach to explain data analysis methods
        2. Coverage of genotyping methods
          1. Inclusion of a post-GWAS bioinformatics approach to analysing statistical results
              1. Consideration of the environment as an important player in disease genetics
              2. Includes the use of association studies in medical practice and genetic risk profiling

          2. Contents

            1. Primer on Molecular Genetics

            2. Primer on Medical Genetics

            3. Primer on Population Genetics

            4. Epidemiologic Principles and Genetic Association Studies

            5. Environmental Epidemiology in the Context of Genetic Epidemiology

            6. Elementary Statistical Concepts

            7. Genotyping Methods and Errors

            8. Candidate Gene Studies and Genome-Wide Association Studies

            9. Statistical Analysis of Genetic Association Study Results

            10. Bioinformatics for the Interpretation of Genetic Association Study Results

            11. Genetic Risk Profiling and Medical Applications of Genetic Associations

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