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Genomes 4

Edition:
4th
Author(s):
T. Brown
ISBN:
9780815345084
Format:
Paperback
Publication Date:
April 30, 2017
Content Details:
600 pages | 500 illustrations
Language:
English

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List Price:   $120.00

  
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  • About the Book

    Book Summary

    The 4th edition of Genomes has been completely revised and updated to make it a thoroughly modern textbook about genomes and how they are investigated. As with the 3rd edition, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution.  The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids.

    Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Genome sequencing and assembly methods have been totally revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding.

    Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is therefore ideal text for upper level courses focused on genomes and genomics.

    Features

      • Completely updated and rewritten, including 150 new figures, to make it into a genomic textbook

      • Same structure as Genomes 3 but streamlined

      • Genomes from a wide variety of organism included, from viruses to humans

      • Techniques fully integrated into the text

      • Techniques for investigating the genome, transcriptome, and proteome included

      • Coverage of expression, regulation, and evolution is on a genomic scale

      • Short answer questions and in-depth problems at the end of each chapter

       

  • Contents

    PART 1 HOW GENOMES ARE STUDIED
    1. Genomes, Transcriptomes and Proteomes
    2. Studying DNA
    3. Mapping Genomes
    4. Sequencing Genomes
    5. Genome Annotation
    6. Identifying Gene Functions
    PART 2 GENOME ANATOMIES
    7. Eukaryotic Nuclear Genomes
    8. Genomes of Prokaryotes and Eukaryotic Organelles
    9. Virus Genomes and Mobile Genetic Elements
    PART 3 HOW GENOMES ARE EXPRESSED
    10. Accessing the Genome
    11. The Role of DNA-Protein Interactions in Genome Expression
    12. Transcriptomes
    13. Proteomes
    14. Genome Expression in the Context of Cell and Organism
    PART 4 HOW GENOMES ARE REPLICATED AND EVOLVE
    15. Genome Replication
    16. Mutations and DNA Repair
    17. Recombination and Transposition
    18. How Genomes Evolve

  • Instructor Resources

    Instructor Resources

    Book figures available as JPEGs and powerpoint slides

    Answer guide to questions in the book

    Glossary

  • Student Resources

    Student Resources

    Book figures available as JPEGs

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