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The Biology of Cancer

Robert A. Weinberg, Robert A Weinberg
Publication Date:
May 24, 2013
Content Details:
960 pages | 583 illustrations

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  • About the Book

    Book Summary

    Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.

    The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

    The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on:

    • The tumor microenvironment
    • Metastatic dissemination
    • Tumor immunology
    • Cancer stem cells
    • The epithelial-mesenchymal transition
    • Multi-step tumorigenesis
    • Invasion and metastasis
    • Mutation of cancer cell genomes
    • Greatly expanded treatment of traditional therapy
    • Epigenetic contributions
    • MicroRNA involvement
    • The Warburg effect

    Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals.

    Every copy of the book comes with an updated "Pathways in Human Cancer" poster and a DVD-ROM containing the book’s art program, a greatly expanded selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide.


      • CONCEPT HEADINGS- These introduce each section of the text and help the student focus on, and review, key ideas.
      • SIDEBARS- Contain additional information or anecdotes pertinent to the discussion that are set aside so as not to disrupt the logical flow of the main text.
      • SYNOPSIS AND PROSPECTS- This section places the topic of that chapter into a larger perspective while providing a summary, and a link to later chapters. In these sections the author speculates about future research.
      • KEY CONCEPTS- A summary of the chapter’s essential points, in list form, to aid in review.
      • THOUGHT QUESTIONS- Designed to provide review, analysis and to provoke discussion.
      • REFERENCES- An extensive list of pertinent articles and books for those who want to delve deeper into a topic.
      • LIST OF KEY TECHNIQUES- The major techniques referred to throughout the text are indexed separately.      
      • GLOSSARY- Defines terms in bold and italics within the text.
      • LIST OF ACRONYMS AND ABBREVIATIONS- A handy reference that helps readers navigate through the nomenclature of the primary research literature.


      "The book fulfills its purpose and is, indeed, a must-read for students of cancer biology…It includes updated information and concepts in cancer research that justify replacing the previous edition."
      - Doody Reviews

      "This publication represents an exhaustive and detailed coverage of the field of basic oncology oriented toward a student audience, and it continues to set the highest example of excellence in the field of undergraduate and graduate oncology." - The Quarterly Review of Biology

      "Clearly, not only is it an authoritative text book on the complex biology of cancer, it serves as an invaluable reference document for individuals working in biomedical laboratories as well as professionals involved in day to day management of cancer in the clinics." - Oncology News

      Praise for the First Edition of THE BIOLOGY OF CANCER by Robert A. Weinberg:

      “There is no comparable text in cancer biology…”
      - Nature

      “The Biology of Cancer is no doubt the definitive statement on its topic today.”
      - Science

      “Here, at last, we have a definitive textbook specifically devoted to the molecular and cell biology of cancer.”
      - Bioscience Education

      “Overall, this is a remarkable achievement that is by far the most comprehensive coverage of this field available.”
      - Times Higher Education Supplement

  • Contents

    1. The Biology and Genetics of Cells and Organisms
    2. The Nature of Cancer
    3. Tumor Viruses
    4. Cellular Oncogenes
    5. Growth Factors, Receptors, and Cancer
    6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
    7. Tumor Suppressor Genes
    8. pRb and Control of the Cell Cycle Clock
    9. p53 and Apoptosis: Master Guardian and Executioner
    10. Eternal Life: Cell Immortalization and Tumorigenesis
    11. Multi-step Tumorigenesis
    12. Maintenance of Genomic Integrity and the Development of Cancer
    13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis
    14. Moving Out: Invasion and Metastasis
    15. Crowd Control: Tumor Immunology and Immunotherapy
    16. The Rational Treatment of Cancer
  • Instructor Resources

    Instructor Resources

    For the following resources, verified instructors can visit the resource page for The Biology of Cancer, Second Edition.

    • Figures in PowerPoint® and JPEG formats.
    • Movies with narration cover selected topics.
    • Audio files of mini-lectures by the author.
    • “Pathways in Human Cancer” poster included in book and in PDF format.
    • Supplementary Sidebars.
    • Media Guide.
    • A Question Bank containing 10 to 15 questions for each chapter is available for instructors only.

    Except for the Question Bank, these resources are also available on the DVD-ROM that accompanies the book.

  • Student Resources

    Student Resources

    For the following resources, students can visit the resource page for The Biology of Cancer, Second Edition.

    • Figures in PowerPoint® and JPEG formats.
    • Movies with narration cover selected topics.
    • Audio files of mini-lectures by the author.
    • Online flashcards and glossary.
    • “Pathways in Human Cancer” poster included in book and PDF format.
    • Supplementary Sidebars.
    • Media Guide.

    For the movies, audio files, and online flash cards and glossary, students can visit the student resource page for The Biology of Cancer, Second Edition. Except for the online flash card and glossary, these resources are also available on the DVD-ROM that accompanies the book.

  • E-book and Custom Pub

    E-book and Custom Publishing


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