- Lyle Armstrong
- Publication Date:
- November 25, 2013
- Content Details:
- 300 pages | 122 illustrations
Also of Interest
The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does.
Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals.
• The two forms of epigenetic modification, DNA methylation and histone acetylation, and how they take place.
• How epigenetics controls cell function, including cellular differentiation and the role of epigenetics in stem cells.
• The role of epigenetics in disease, including cancer and mental health, where there is clear evidence of epigenetic involvement.
- "The author has made a very thorough presentation of several areas within the field of epigenetics. The material has been presented in a comprehensive, well-organized and understandable manner. He allows the reader to gain a strong foundation of each subject area by including detailed introductory sections. The coverage of the topics will allow the reader to obtain both general knowledge and also more detailed understanding of the regulating mechanisms involved in epigenetic changes and the consequences of those changes. The content is also relevant to current trends in the field of epigenetics and includes reviews of disease states related to epigenetics, such as cancer, which are actively being researched."
Chapter 1. Introduction to the Study of Epigenetics
Chapter 2. The Basis of the Transcription Process
Chapter 3. DNA Packaging and Chromatin Architecture
Chapter 4. Modifying the Structure of Chromatin
Chapter 5. DNA Methylation
Chapter 6. Post-Translational Modification of Histones
Chapter 7. Histone Modification Machinery
Chapter 8. Locus-Specific Control of Histone-Modifying Enzyme Action
Chapter 9. Epigenetic Control of Cell-Specific Gene Expression
Chapter 10. Epigenetic Control of the Mitotic Cell Cycle
Chapter 11. The Epigenetic Basis of Gene Imprinting
Chapter 12. Epigenetic Control of Cellular Differentiation
Chapter 13. Reversibility of Epigenetic Modification Patterns
Chapter 14. Epigenetic Predisposition to Disease and Imprinting-Based Disorders
Chapter 15. Epigenetics of Memory, Neurodegeneration, and Mental Health
Chapter 16. Epigenetics of Cancer
Full-color artwork in JPEG and PowerPoint® formats for qualified instructors.
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