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Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Paul C.H. Li
Publication Date:
February 24, 2010
Content Details:
418 pages

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  • About the Book

    Book Summary

    Lab-on-a-chip technology permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. Using this technology, biological and biochemical analyses translate into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field’s pioneering researchers, Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery focuses on all key aspects of microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances.

    The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.

    The book includes more than 300 figures that depict novel chip functions and breakthroughs and 16 tables summarize materials and refer readers to additional resources. An appendix compiles extensive analytical applications from emerging and established research groups.

    Beginners in the field will find the book useful for navigating the vast literature related to the technology, while experienced researchers will rely on the compiled information for easy comparison and references for further study.

    Derived from the highly popular Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery (2006), this volume is also readily adaptable for classroom use. Problem sets in each chapter help students test their assimilation of the material and clarify challenging concepts. The book contains a comprehensive glossary, a complete index, and extensive references. A solutions manual is available with qualifying course adoption.


      • Reviews fundamentals of micromachining and fluid flow and control for lab-on-a-chip
      • Emphasizes analytical applications of microfluidic technology
      • Includes information that is key to cell, nucleic acid, protein, and genetic analyses, including DNA sequencing
      • Adapts traditional principles of operations for the size of a chip, optimizing the miniaturization advantage and favorable scaling down
      • Contains tables that summarize related materials and problem sets that test comprehension of the material
      • Includes a glossary and extensive references along with a four-page color insert

      Solutions manual is available upon qualifying course adoption

  • Contents

    Micromachining Methods
    Micromachining of Silicon
    Micromachining of Glass
    Micromachining of Fused Quartz (or Fused Silica)
    Micromachining of Polymeric Chips
    Metal Patterning
    World-to-Chip Interface
    Problem Sets
    Microfluidic Flow
    Liquid Pumping Methods
    Microfluidic Flow Control
    Problem Sets
    Sample Introduction
    Electrokinetic Injection
    Hydrodynamic Injection
    Other Sample Injection Methods
    Problem Sets
    Sample Preconcentration
    Sample Stacking
    Porous Membrane
    Other Preconcentration Methods
    Problem Sets
    Gas Chromatography (GC)
    Capillary Electrophoresis (CE)
    Chromatographic Separations
    Coupled Separations
    Problem Sets
    Detection Methods
    Optical Detection Methods
    Electrochemical (EC) Detection
    Mass Spectrometry (MS)
    Other Detection Methods
    Problem Sets
    Applications to Cellular/Particle Analysis
    Retention of Cells and Particles
    Studies of Cells in a Flow
    Other Cell Operations
    Problem Sets
    Applications to Nucleic Acids Analysis
    Nucleic Acids Extraction and Purification
    Nucleic Acids Amplification
    DNA Hybridization
    Other Nucleic Acid Applications
    Problem Sets
    Applications to Protein Analysis
    Protein Separation
    Enzymatic Assays
    Problem Sets