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Quantitative Biology

From Molecular to Cellular Systems

Michael E. Wall
Publication Date:
August 25, 2012
Content Details:
392 pages | 21 illustrations

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List Price:   $105.00

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  • About the Book

    Book Summary

    Quantitative methods are revolutionizing modern molecular and cellular biology. Groundbreaking technical advances are fueling the rapid expansion in our ability to observe, as seen in multidisciplinary studies that integrate theory, computation, experimental assays, and the control of microenvironments. Integrating new experimental and theoretical methods, Quantitative Biology: From Molecular to Cellular Systems gives both new and established researchers a solid foundation for starting work in this field.

    The book is organized into three sections:

    • Fundamental Concepts covers bold ideas that inspire novel approaches in modern quantitative biology. It offers perspectives on evolutionary dynamics, system design principles, chance and memory, and information processing in biology.
    • Methods describes recently developed or improved techniques that are transforming biological research. It covers experimental methods for studying single-molecule biochemistry, small-angle scattering from biomolecules, subcellular localization of proteins, and single-cell behavior. It also describes theoretical methods for synthetic biology and modeling random variations among cells.
    • Molecular and Cellular Systems focuses on specific biological systems where modern quantitative biology methods are making an impact. It incorporates case studies of biological systems for which new concepts or methods are increasing our understanding. Examples include protein kinase at the molecular level, the genetic switch of phage lambda at the regulatory system level, and Escherichia coli chemotaxis at the cellular level.

    In short, Quantitative Biology presents practical tools for the observation, modeling, design, and manipulation of biological systems from the molecular to the cellular levels.


      • Provides an introductory overview of the field emphasizing fundamental concepts and methodology
      • Illustrates how quantitative methods are applied to increase our understanding of biological systems from the molecular to cellular levels
      • Covers a broad spectrum of quantitative approaches such as single molecule biochemistry, single cell behavior, and modeling cell-to-cell variations
      • Includes detailed descriptions of important examples, from transcription to cell signaling and chemotaxis
  • Contents

    Free Energies, Landscapes, and Fitness in Evolution Dynamics, Robert H. Austin
    System Design Principles, Michael A. Savageau
    Chance and Memory, Theodore J. Perkins, Andrea Y. Wei├če, and Peter S. Swain
    Information Theory and Adaptation, Ilya Nemenman
    Quantitative In Vitro Biochemistry, One Molecule at a Time, Jeffrey A. Hanson and Haw Yang
    Small-Angle Scattering, Cy M. Jeffries and Jill Trewhella
    Subcellular Signaling Dynamics, Jeffrey J. Saucerman and Jin Zhang
    Single-Cell Behavior, Philippe Cluzel
    Modeling Genetic Parts for Synthetic Biology, Ying-Ja Chen, Kevin Clancy and Christopher A. Voigt
    Modeling Cellular Variability, Brian Munsky
    PKA: Prototype for Dynamic Signaling in Time and Space, Susan S. Taylor and Alexandr P. Kornev
    Stochastic Simulation of the Phage Lambda Gene Regulatory Circuitry, John W. Little and Adam P. Arkin
    Chemotaxis, Howard C. Berg