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Advanced Practical Organic Chemistry, Third Edition

Edition:
3rd
Author(s):
John Leonard, Barry Lygo, Garry Procter
ISBN:
9781439860977
Format:
Paperback
Publication Date:
January 08, 2013
Content Details:
356 pages
Language:
English

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List Price:   $81.00

  
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  • About the Book

    Book Summary

    Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions.

    This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics:

    • Record keeping and equipment
    • Solvent purification and reagent preparation
    • Using gases and working with vacuum pumps
    • Purification, including crystallization and distillation
    • Small-scale and large-scale reactions
    • Characterization, including NMR spectra, melting point and boiling point, and microanalysis
    • Efficient ways to find information in the chemical literature

    With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.

    Features

      • Provides a fully revised edition of a bestselling textbook
      • Presents a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis
      • Draws on the experience of the authors and their association with some of the world’s leading laboratories of synthetic organic chemistry
      • Contains many illustrations, all of which have been redrawn for this edition

    Reviews

      Praise for the Second Edition:
      "… an essential purchase for all new research students in the area of organic synthesis."
      Synthesis

      "This book should be present in every organic chemistry research laboratory…"
      Chemistry & Industry

      "Reading this book is like having a thoughtful and smart tutor guiding all your steps in the laboratory … excellent choice."
      Physical Sciences Educational Reviews

  • Contents

    General introduction

    Safety
    Safety is your primary responsibility
    Safe working practice
    Safety risk assessments
    Common hazards
    Accident and emergency procedures
    Bibliography

    Keeping records of laboratory work
    Introduction
    The laboratory notebook
    Keeping records of data
    Some tips on report and thesis preparation
    References

    Equipping the laboratory and the bench
    Introduction
    Setting up the laboratory
    General laboratory equipment
    The individual bench
    Equipment for parallel experiments
    Equipment for controlled experimentation

    Purification and drying of solvents
    Introduction
    Purification of solvents
    Drying agents
    Drying of solvents
    References

    Reagents: Preparation, purification, and handling
    Introduction
    Classification of reagents for handling
    Techniques for obtaining pure and dry reagents
    Techniques for handling and measuring reagents
    Preparation and titration of simple organometallic reagents and lithium amide bases
    Preparation of diazomethane
    References

    Gases
    Introduction
    Use of gas cylinders
    Handling gases
    Measurement of gases
    Inert gases
    Reagent gases
    References

    Vacuum pumps
    Introduction
    House vacuum systems (low vacuum)
    Medium vacuum pumps
    High vacuum pumps
    Pressure measurement and regulation

    Carrying out the reaction
    Introduction
    Reactions with air-sensitive reagents
    Reaction monitoring
    Reactions at other than room temperature
    Driving equilibria
    Agitation
    Use of controlled reactor systems
    References

    Working up the reaction
    Introduction
    Quenching the reaction
    Isolation of the crude product
    Data that need to be collected on the crude product prior to purification

    Purification
    Introduction
    Crystallization
    Distillation
    Sublimation
    Flash chromatography
    Dry-column flash chromatography
    Preparative TLC
    Medium pressure and prepacked chromatography systems
    Preparative HPLC
    References

    Small-scale reactions
    Introduction
    Reactions at or below room temperature
    Reactions above room temperature
    Reactions in NMR tubes
    Purification of materials

    Large-scale reactions
    Introduction
    Carrying out the reaction
    Workup and product isolation
    Purification of the products

    Special procedures
    Introduction
    Catalytic hydrogenation
    Photolysis
    Ozonolysis
    Flash vacuum pyrolysis (FVP)
    Liquid ammonia reactions
    Microwave reactions
    References

    Characterization
    Introduction
    NMR spectra
    IR spectra
    UV spectroscopy
    Mass spectrometry
    Melting point (m.p.) and boiling point (b.p.)
    Optical rotation
    Microanalysis
    Keeping the data

    Troubleshooting: What to do when things don’t work

    The chemical literature
    The structure of the chemical literature
    Some important paper-based sources of chemical information
    Some important electronic-based sources of chemical information
    How to find chemical information
    Current awareness
    References

    Appendices
    Properties of common solvents
    Properties of common gases
    Approximate pKa values for some common reagents versus common bases
    Common Bronsted acids
    Common Lewis acids
    Common reducing reagents
    Common oxidizing reagents

    Index