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Bacterial Protein Toxins

Publication Date:
January 22, 2003
Content Details:
348 pages

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  • About the Book

    Book Summary

    Details how these proteins work while providing a review of the field. • Describes all aspects of the biology of toxins, including their synthesis and secretion from the bacterial cell, their travels to and into the target host cell, and their modes of attacking the host cell machinery. • Illustrates how bacterial toxins, each of which has distinct individual properties, often share mechanisms of secretion, membrane transport, and enzymatic action.

    This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

  • Contents

    Table of Contents I. Genetics and Regulation Two Component Systems, Scott Stibitz Regulation of Bacterial Toxin Synthesis by Iron, Shelley M. Payne AraC Family Regulators and Transcriptional Control of Bacterial Virulence Determinants, Dara W. Frank and Meredith L. Hunt Quorum Sensing, Everett C. Pesci and Barbara H. Iglewski II. Toxin Biogenesis: Crossing Bacterial Membrane Barriers Box 1: Type V Export Systems, Proteins That Export Themselves, Drusilla L. Burns The Type I Export Mechanism, Vassilis Koronakis, Jeyanthy Eswaran, and Colin Hughes Toxins and Type II Secretion Systems, Maria E. Scott and Maria Sandkvist Type III Secretion Systems, Gregory V. Plano, Kurt Schesser, and Matthew L. Niles Box 2: Pathogenicity Islands, Jorg Hacker Type IV Secretion Systems, Drusilla L. Burns III. Toxin Delivery Into Eukaryotic Cells Receptors for Bacterial Toxins, Catharine B. Saelinger Box 3: Domain Structures of Bacterial Toxins, Stephen H. Leppla Box 4: Recombinant Immunotoxins, David J. FitzGerald, Robert J. Kreitman, and Ira Pastan Direct Penetration of Bacterial Toxins Across the Plasma Membrane, Franca R. Zaretzky, Mary C. Gray, and Erik L. Hewlett Transport of Toxins Across Intracellular Membranes, Kirsten Sandvig Transcytosis of Bacterial Toxins Across Mucosal Barriers, Bonny L. Dickinson and Wayne I. Lencer Box 5: Lipid Rafts, Bonny L. Dickinson and Wayne I. Lencer IV. Toxin Action Membrane-Damaging Toxins: Pore Formation, F. Gisou van der Goot Box 6: The Vacuolating Toxin VacA of Helicobacter pylori, F. Gisou van der Goot Membrane-Damaging Toxins: Family of RTX Toxins, Camilla Oxhamre and Agneta Richter-Dahlfors Bacterial Toxins that Covalently Modify Eukaryotic Proteins by ADP-Ribosylation, Joseph T. Barbieri and Drusilla L. Burns Box 7: Discovery that the Active Sites of Pseudomonas aeruginosa Exotoxin A and the Heat-Labile Enterotoxin of Escherichia coli Are Superimposable, Wim Hol Glucosylating and Deamidating Bacterial Protein Toxins, Klaus Aktories Plant and Bacterial Toxins as RNA N-Glycosidases, Angela Melton-Celsa and Alison D. O'Brien Cytolethal Distending Toxin, Lawrence A. Dreyfus Proteases, Ornella Rossetto, Fiorella Tonella, and Cesare Montecucco Box 8: Landmarks in Tetanus and Botulinum Research, Ornella Rossetto, Fiorella Tonella, and Cesare Montecucco Bacterial Toxins that Modulate Rho GTPase Activity, James B. Bliska and Gloria I. Viboud Staphylococcal and Streptococcal Superantigens, Patrick M. Schlievert V. Bacterial Toxins: Friends and Foes Toxins as Vaccines and Adjuvants, Mariagrazia Pizza, Vega Masignani, and Rino Rappuoli Nefarious Uses of Bacterial Toxins, Drusilla L. Burns and Joseph T. Barbieri