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DNA Repair and Mutagenesis

Errol C Friedberg, Graham C Walker, Wolfram Siede, Richard D Wood
Publication Date:
November 22, 2005
Content Details:
1,164 pages

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  • About the Book

    Book Summary

    An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

    This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

  • Contents

    Table of Contents Part 1. Sources and Consequences of DNA Damage 1. Introduction: Biological Responses to DNA Damage 2. DNA Damage 3. Introduction to Mutagenesis Part 2. Correcting Altered Bases in DNA: DNA Repair 4. Reversal of Base Damage Caused by UV Radiation 5. Reversal of Alkylation Damage in DNA 6. Base Excision Repair 7. Nucleotide Excision Repair: General Features and the Process in Prokaryotes 8. Nucleotide Excision Repair in Eukaryotes: Cell Biology and Genetics 9. Mechanism of Nucleotide Excision Repair in Eukaryotes 10. Heterogeneity of Nucleotide Excision Repair in Eukaryotic Genomes 11. Alternative Excision Repair of DNA 12. Mismatch Repair 13. Repair of Mitochondrial DNA Damage Part 3. DNA Damage Tolerance and Mutagenesis 14. The SOS Responses of Prokaryotes to DNA Damage 15. Mutagenesis and Translesion Synthesis in Prokaryotes 16. Recombinational Repair, Replication Fork Repair, and DNA Damage Tolerance 17. DNA Damage Tolerance and Mutagenesis in Eukaryotic Cells 18. Managing DNA Strand Breaks in Eukaryotic Cells: Repair Pathway Overview and Homologous Recombination 19. Managing DNA Strand Breaks in Eukaryotic Cells: Nonhomologous End Joining and Other Pathways Part 4. Regulatory Responses to DNA Damage in Eukaryotes 20. Cell Cycle Checkpoints: General Introduction and Mechanisms of DNA Damage Sensing 21. Cell Cycle Checkpoints: Signal Transmission and Effector Targets 22. Transcriptional Responses to DNA Damage 23. DNA Damage and the Regulation of Cell Fate Part 5. Disease States Associated with Defective Biological Responses to DNA Damage 24. Xeroderma Pigmentosum: a Disease Associated with Defective Nucleotide Excision Repair or Defective Translesion DNA Synthesis 25. Other Diseases Associated with Defects in Nucleotide Excision Repair of DNA 26. Diseases Associated with Defective Responses to DNA Strand Breaks 27. Diseases Associated with Disordered DNA Helicase Function 28. Additional Diseases Associated with Defective Responses to DNA Damage 29. Hereditary Diseases that Implicate Defective Responses to DNA Damage 30. DNA Polymorphisms in Gatekeeper and Guardian Genes Appendix Table 1. Nomenclature of DNA repair genes Table 2. Human hereditary diseases and defective cellular responses to DNA damage