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Pathogenesis of Human Pulmonary Tuberculosis

Insights from the Rabbit Model

Publication Date:
August 29, 2006
Content Details:
453 pages

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  • About the Book

    Book Summary

    Examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the rabbit model. • Reviews the interplay of delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses. • Covers the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development. • Focuses on areas of future research that could contribute to the knowledge, treatment, and control of this disease. • Serves as a resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology.
  • Contents

    Table of Contents Introduction Section 1. Pathogenesis of Tuberculosis 1. Overview 2. Stages in the Pathogenesis of Human and Rabbit Tuberculosis 3. Types of Human Pulmonary Tuberculosis 4. Liquefaction of Caseous Foci and Cavity Formation Section 2. Immunology of Tuberculosis 5. Delayed-Type Hypersensitivity, Cell-Mediated Immunity, and Antibodies in Tuberculosis 6. Macrophages and Other Cells in Tuberculosis Lesions Section 3. Tuberculous Lesions 7. Structural Components of Tuberculous Lesions 8. Microvascular Density in Tuberculosis Lesions 9. Early Pulmonary Lesions in Rabbits 10. Macrophage Turnover, Division, and Activation in Tuberculosis Lesions 11. Lurie's Pulmonary Tubercle-Count Method Section 4. Tuberculosis in Rabbits and Other Common Laboratory Animals 12. Natural Airborne Infection 13. Response of Rabbits to Inhaled Tubercle Bacilli Including BCG 14. Characteristics of Resistance and Susceptibility to Tuberculosis in Lurie's Inbred Rabbit 15. Comparisons of Tuberculosis in Rabbits, Mice, and Guinea Pigs Section 5. Effects of Hormones and X-Irradiation on Tuberculosis 16. Effects of Cortisone and Adrenocorticotropic Hormone on Tuberculosis 17. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis 18. Effects of Whole-Body X-Irradiation on Tuberculosis Section 6. Cytokines and Vascular Adhesion Molecules in Tuberculous Lesions 19. Cytokine Production in Primary BCG Lesions 20. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions 21. Vascular Adhesion Molecules in Tuberculous Lesion Section 7. Tuberculosis Vaccines 22. Principles and Guidelines for Developing Better Tuberculosis Vaccines 23. Characteristics of Rabbit BCG Lesions and Efficacies of BCG and Mycobacterium microti Vaccines Section 8. Past, Present, and Future 24. Summary and Conclusions 25. Suggested Future Research and Unanswered Questions Appendixes A. Award of the Trudeau Medal of the National Tuberculosis Association to Max B. Lurie B. Obituary of Max B. Lurie C. Publications of Max B. Lurie D. Publications of Arthur M. Dannenberg, Jr. E. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 (Centers for Disease Control and Prevention; Table of Contents) F. Collected Abstracts of Chapters in This Volume G. Acknowledgments Glossary