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Virulence Mechanisms of Bacterial Pathogens

Publication Date:
July 26, 2016
Content Details:
871 pages

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List Price:   $160.00

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  • About the Book

    Book Summary

    Ground-breaking overview of an enduring topic

    Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies.

    A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses,  and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including
    • how metabolism shapes the host-pathogen interface
    • interactions across species and genera
    • mechanisms of the secretion systems
    • evasion, survival, and persistence mechanisms
    • new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens

    Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.


    • Presents a compilation of bacterial virulence strategies and cutting-edge therapies that have been unraveled in recent years.
    • Serves as a textbook for graduate courses on bacterial pathogenesis.
    • Also a useful resourse for veterinary scientists, food microbiologists, and other established researchers interested in pathogenesis.
    • The 5th volume in a series of books on the variety of mechanisms used by bacterial pathogens in establishing infection, producing disease, and persisting in the host.


      “This new edition of Virulence Mechanisms of Bacterial Pathogens is edited by renowned experts in the field, and encompasses state-of-the-art review articles and critical overviews. From bacterial:host interactions and communication to bacterial secretion systems, persistence, and novel targeted therapies, this is a ‘MUST READ’ for anyone studying bacterial infectious agents.”

      Carolyn Hovde Bohach, Ph.D., University Distinguished Professor, University of Idaho School of Food Science; Director, NIH Idaho INBRE Program;

      President, National Association of IDeA Principal Investigators (NAIPI)

  • Contents

    Contributors ix
    Preface xv
    Acknowledgments xvii
    Section Editor: Nancy A. Cornick
    1 Evolution of Bacterial Pathogens Within the Human Host 3
    Kimberly A. Bliven and Anthony T. Maurelli
    2 Bacterial Metabolism Shapes the Host–Pathogen Interface 15
    Karla D. Passalacqua, Marie-Eve Charbonneau, and Mary X.D. O’Riordan
    3 Iron Acquisition Strategies of Bacterial Pathogens 43
    Jessica R. Sheldon, Holly A. Laakso, and David E. Heinrichs
    Section Editor: Paul J. Plummer
    4 Sociomicrobiology and Pathogenic Bacteria 89
    Joao B. Xavier
    5 Candida-Bacteria Interactions: Their Impact on Human Disease 103
    Devon L. Allison, Hubertine M. E. Willems, J.A.M.S. Jayatilake, Vincent M. Bruno,
    Brian M. Peters, and Mark E. Shirtliff
    6 Microbial Endocrinology in the Pathogenesis of Infectious Disease 137
    Mark Lyte
    7 Small RNAs in Bacterial Virulence and Communication 169
    Sarah L. Svensson and Cynthia M. Sharma
    Section Editor: Indira T. Kudva
    8 Bacterial Secretion Systems: An Overview 215
    Erin R. Green and Joan Mecsas
    9 The Structure and Function of Type III Secretion Systems 241
    Ryan Q. Notti and C. Erec Stebbins
    10 Mechanism and Function of Type IV Secretion During Infection
    of the Human Host 265
    Christian Gonzalez-Rivera, Minny Bhatty, and Peter J. Christie
    11 Type V Secretion Systems in Bacteria 305
    Enguo Fan, Nandini Chauhan, D. B. R. K. Gupta Udatha,
    Jack C. Leo, and Dirk Linke
    12 The Versatile Type VI Secretion System 337
    Christopher J. Alteri and Harry L.T. Mobley
    13 Type VII Secretion: A Highly Versatile Secretion System 357
    Louis S. Ates, Edith N. G. Houben, and Wilbert Bitter
    Section Editor: Qijing Zhang
    14 Stress Responses, Adaptation, and Virulence of Bacterial Pathogens
    During Host Gastrointestinal Colonization 387
    Annika Flint, James Butcher, and Alain Stintzi
    15 Bacterial Evasion of Host Antimicrobial Peptide Defenses 413
    Jason N. Cole and Victor Nizet
    16 Antigenic Variation in Bacterial Pathogens 445
    Guy H. Palmer, Troy Bankhead, and H. Steven Seifert
    17 Mechanisms of Antibiotic Resistance 481
    Jose M. Munita and Cesar A. Arias
    Section Editor: Tracy L. Nicholson
    18 Chronic Bacterial Pathogens: Mechanisms of Persistence 515
    Mariana X. Byndloss and Renee M. Tsolis
    19 The Staphylococcal Biofilm: Adhesins, Regulation,
    and Host Response 529
    Alexandra E. Paharik and Alexander R. Horswill
    20 Surviving Between Hosts: Sporulation and Transmission 567
    Michelle C. Swick, Theresa M. Koehler, and Adam Driks
    21 Staying Alive: Vibrio cholerae’s Cycle of Environmental Survival,
    Transmission, and Dissemination 593
    Jenna G. Conner, Jennifer K. Teschler, Christopher J. Jones,
    and Fitnat H. Yildiz
    Section Editor: John P. Bannantine
    22 Hijacking and Use of Host Lipids by Intracellular Pathogens 637
    Alvaro Toledo and Jorge L. Benach
    23 Contrasting Lifestyles Within the Host Cell 667
    Elizabeth Di Russo Case and James E. Samuel
    24 Intracellular Growth of Bacterial Pathogens: The Role of Secreted
    Effector Proteins in the Control of Phagocytosed Microorganisms 693
    Valérie Poirier and Yossef Av-Gay
    25 Cellular Exit Strategies of Intracellular Bacteria 715
    Kevin Hybiske and Richard Stephens
    Section Editor: Bryan H. Bellaire
    26 Novel Targets of Antimicrobial Therapies 741
    Sarah E. Maddocks
    27 Innovative Solutions to Sticky Situations: Antiadhesive Strategies for
    Treating Bacterial Infections 753
    Zachary T. Cusumano, Roger D. Klein, and Scott J. Hultgren
    28 The Role of Biotin in Bacterial Physiology and Virulence: a Novel
    Antibiotic Target for Mycobacterium tuberculosis 797
    Wanisa Salaemae, Grant W. Booker, and Steven W. Polyak
    29 Recent Advances and Understanding of Using Probiotic-Based
    Interventions to Restore Homeostasis of the Microbiome for the
    Prevention/Therapy of Bacterial Diseases 823
    Jan S. Suchodolski and Albert E. Jergens
    Index 843