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Peptide Nucleic Acids

Protocols and Applications

Publication Date:
May 01, 1999
Content Details:
304 pages

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  • About the Book

    Book Summary

    Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of peptide nucleic acids. Concepts are clearly explained with each chapter containing concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area.


      This book continues the contribution of the first edition as a valuable introduction to the reader new to the field of PNA as well as a highly useful reference book for experienced researchers and scientists. This book is highly recommended for science, medical and academic libraries supoprting research activity in molecular biology. - E-Streams Vol. 8, No. 5 - May 2005

      This books is an excellent guide to PNAs and I would recommend it highly for anyone wanting an up-to-date and detailed text on this technology. - Dr Helena Ward, Australian Journal of Medical Science, May 2005, Vol 26, No. 2

  • Contents

    1. An Introduction to PNA. 2. PNA Synthesis by Boc Chemistry, T. Koch 3. Synthesis of PNA Oligomers by Fmoc Chemistry, R. Casale. 4. Thermodynamics of PNA Interactions. 5. Peptide Nucleic Acid Targeting of Double-Stranded DNA. 6. PNA Beacons and Fluoroprobes. 7. Vector Tagging Via PNA. 8. PCR Clamping. 9. PNA Directed Genome Rare Cutting: New Developments. 10. PNA Openers for Duplex DNA: Basic Facts, Fine Tuning and Emerging Applications. 11. Combined Use of PNA and DNA for Fluorescence In Situ Hybridization (FISH). 12. Production of PNA-Arrays for Nucleic Acid Detection. 13. PNA Antisense in Eukaryotic Systems. 14. Antisense Effects in Escherichia coli.