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Julian M. Ketley, Michael E. Konkel
Publication Date:
February 10, 2005
Content Details:
470 pages

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  • About the Book

    Book Summary

    The publication of the complete sequence of the C. jejuni genome in 2000 provided new insight into this leading gastrointestinal pathogen and presented scientists with an exciting resource to improve our understanding of the biology of this bacterium. In this book internationally recognised Campylobacter experts critically review the most important aspects of Campylobacter research, providing the first coherent picture of the organism’s molecular and cellular biology since the publication of the genome.

    Most contributions are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Introductory chapters explore the taxonomy, genetic diversity, habitats, and epidemiological analysis of campylobacters. Other chapters review Campylobacter plasmid biology, antimicrobial resistance, stress response, motility, chemotaxis, metabolism and bioenergetics of C. jejuni, and polysaccharide biosynthesis (including lipooligosaccharide, capsule biosynthesis, and protein glycosylation). The final chapters focus more directly on interactions with the host, for example, the mechanisms of host cell invasion, interactions with phagocytes, and the use of microarrays to analyze gene expression in response to infection by C. jejuni. Each chapter is independent and can be read in isolation, but as a whole the book provides an important resource summarising our current knowledge of Campylobacter molecular and cellular biology.

    Essential reading for all researchers working with Campylobacter and related organisms.

  • Contents

    1. Campylobacter Infection. 2. Taxonomy, Phylogeny, and Methods for the Identification of Campylobacter Species. 3. Population Genetics of Campylobacter jejuni. 4. Campylobacter jejuni Strain Variation. 5. Advances in Campylobacter jejuni Comparative Genomics Through Whole Genome DNA Microarrays. 6. Prevalence of Campylobacter in the Food and Water Supply: Incidence, Outbreaks, Isolation, and Detection. 7. New Methods for Epidemiological Analysis of Campylobacter jejuni. 8. Plasmids of Campylobacter jejuni 81-176. 9. Mechanisms of Antimicrobial Resistance in Campylobacter. 10. Multidrug Efflux Systems in Campylobacter. 11. Genetic Bases for the Variation in the Lipooligosaccharide Outer Core of Campylobacter jejuni and Possible Association of Glycosyltransferase Genes with Post-Infectious Neuropathies. 12. The Polysaccharide Capsule of Campylobacter jejuni. 13. Protein Glycosylation in Campylobacter. 14. Metabolism, Electron Transport and Bioenergetics of Campylobacter jejuni: Implications for Understanding Life in the Gut and Survival in the Environment. 15. Iron Transport and Regulation. 16. Campylobacter jejuni Stress Responses During Survival in the Food Chain and Colonisation.17. Motility. 18. Campylobacter Chemotaxis. 19. Invasion. 20. Cytolethal Distending Toxin. 21. Interactions of C. jejuni with Non-professional Phagocytic Cells. 22. Campylobacter jejuni Interactions with Professional Phagocytes. 23. Campylobacter spp and the Ability to Elicit Intestinal Inflammatory Responses. 24. Campylobacter jejuni Interaction with Enterocytes – Using Host Gene Expression Analysis to Unravel.